导师类型

办公地点

6-134

职称/职务

特聘副教授

电子邮箱

sicauwz@163.com

研究方向

水禽的抗病毒天然免疫

受教育及

工作经历

2018-2022四川农业大学博士

2021-2022荷兰语鲁汶大学联合培养

2023-至今四川农业大学动物医学院教师

科研项目

（近五年）

主持：

国家自然科学基金青年科学基金项目-坦布苏病毒切割STING的产物抑制鸭cGAS-STING通路的分子机制-32302885

主研：

1）国家自然科学基金面上项目-新发现的鸭坦布苏病毒非结构蛋白2A内部切割及其调控病毒粒子组装的分子机制-32272976

2）十四五国家重点研发计划“青年科学家项目”-蚊媒传播阻断的干扰素敏感型鸭坦布苏病毒疫苗分子设计的理论和技术研究-2022YFD1801900

3)中国-中东欧国家联合教育项目-蚊媒禽黄病毒非结构蛋白1调控病毒进化和传播的分子基础-2021092

主要论著、

代表性论文

目前发表论文超过11篇，其中第一和共同第一作者8篇，其他作者3篇。

1. Shun Chen,Zhen Wu, Mingshu Wang and Anchun Cheng. Innate immune evasion mediated by flaviviridae non-Structural proteins [J].Viruses-Basel,2017, 9.

2. Shun Chen,Zhen Wu, Anchun Cheng, et al.Duck stimulator of interferon genes plays an important role in host anti-duck plague virus infection through an IFN-dependent signalling pathway [J].Cytokine, 2017, 9.

3.Zhen Wu, Anchun Cheng, Shun Chen, et al.Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-β [J].Journal of Immunology,2019, 12.

4.Zhen Wu, Tao Hu, Anchun Cheng, Shun Chen, et al. The autophagy-related degradation of MDA5 by Tembusu virus nonstructural 2B disrupts IFNβproduction [J].The FASEB Journal,2022, 6.

5.Zhen Wu,Anchun Cheng, Shun Chen, et al. The G92 NS2B mutant of Tembusu virus is involved in severe defects in progeny virus assembly [J].Veterinary Microbiology, 2022, 4.

6.Zhen Wu,Anchun Cheng, Shun Chen, et al. Toll-like receptor 4 and lipopolysaccharide from commensal microbes regulate Tembusu virus infection[J].Journal of Biological Chemistry, 2022,11.

7. Wei Zhang,Zhen Wu, Anchun Cheng, Shun Chen, et al. Binding of Duck Tembusu virus nonstructural protein 2A to duSTING disrupts the induction of its signal transduction cascade to inhibit IFN-β induction [J].Journal of Virology, 2020, 2.

8.Zhen Wu, Yuanyuan Wu, Anchun Cheng, Shun Chen, et al. The First Nonmammalian Pegivirus Demonstrates Efficient In Vitro Replication and High Lymphotropism [J]. Journal of Virology, 2020. 9.

9.Zhen Wu, Yuanyuan Wu, Anchun Cheng, Shun Chen, et al. Emergence of a novel pegivirus species in southwest China showing a high rate of coinfection with parvovirus and circovirus in geese [J].Poultry Science,2021, 8.

10. Tao Hu,Zhen Wu, Shun Chen, Anchun Cheng, et al. The key amino acids of E protein involved in early flavivirus infection: viral entry [J].Virology Journal,2021. 7.

11. Tao Hu,Zhen Wu, Shun Chen, Anchun Cheng, et al.Substitutions at Loop Regions of TMUV E Protein Domain III Differentially Impair Viral Entry and Assembly [J].Frontiers in Microbiology.2021.6.

获奖、新药、新品种等

四川省自然科学二等奖-鸭坦布苏病毒与宿主免疫互作机制3/5